SCIEX Triple Quad 4500 LC-MS/MS System

The SCIEX 4500 Series of mass spectrometers takes the legendary API 4000™ LC-MS/MS system and intelligently re-engineers it to set a new benchmark for reliable quantitation. It offers the quantitative sensitivity, robustness, and performance you need, powered with QTRAP® technology to open a world of valuable experiments beyond MRM for significant data quality improvements for your most challenging methods.Whether your research is focused on ADME, regulated bioanalysis, food and environmental contaminant screening, targeted quantitative proteomics, or clinical research, the SCIEX 4500 Series covers your key performance criteria:

• Quantitative and qualitative sensitivity to detect low concentration analytes in challenging matrices
• Dynamic range to see low to high concentration levels
• Scan speed to clearly resolve similar analytes
• Ionization source flow range for liquid chromatography flexibility
• Uniquely designed to occupy less of your valuable lab spaceAll backed by the integrity and quality of the SCIEX brand.

The LC-MS/MS workhorse, intelligently re-engineered.

Redesigned from the foundation of our industry standard triple quadrupole mass spectrometers, the 4500 Series introduces a new era of LC-MS/MS performance defined by fast, precise quantitation and ultra-fast scan speeds. The system is ideal for UHPLC, and with available QTRAP ® technology you get better data, and more of it, than you can achieve using basic multiple reaction monitoring (MRM) on an ordinary triple quad system.

Fast LC demands short dwell times

Delivering dwell times as low as 1ms, the 4500 complements UHPLC separations to screen for more compounds within a single experiment than ever before. You can maximize your capacity and deliver quality quantitation every time using the powerful ScheduledMRM™ algorithm which automatically optimizes your acquisition method.

Better data. Complete confidence. Unrivalled efficiency. Ultimate performance.

Only SCIEX offers triple quads equipped with Linear Accelerator™ trap technology. The QTRAP 4500 delivers up to a 100-fold increase in full scan MS/MS sensitivity enabling powerful workflows that will give you a new level of confidence in your data.

• Unique scan functionality available only on the QTRAP, allows you to see beyond the matrix to more accurately detect, quantify, and confirm your compounds
• Acquire a complete MS/MS spectrum to accompany your MRM quantitation for every compound detected in your samples and cross reference with an integrated library for ultimate confirmation
• Screen for more compounds in each analysis, without compromising data quality for higher throughput

Diversity delivered

With the quantitative performance of a triple quad system and additional enhanced scan functionality of QTRAP®, you are able to develop new methods and improve results for your existing workflows.

See more clearly beyond the matrix

When your analysis suffers from matrix effects and you’re concerned about the accuracy of your MRM quantitation, QTRAP technology can reduce the worry. The integrated linear ion trap (LIT) enables more accurate detection, quantification, and confirmation of your compounds – without added laborious or time consuming sample prep.

More confidently identify your compounds

For borderline MRM ion ratios, resulting in ambiguous identification, there is a solution. The enhanced product ion (EPI) functionality of QTRAP allows you to acquire a complete MS/MS spectrum to accompany your MRM quantitation for every compound detected in your samples. Cross reference this ‘compound fingerprint’ with an integrated library, and deliver ultimate confirmation and report your analysis without doubt.

More compounds and more samples

If your workload increases, but your time and resources don’t, QTRAP delivers more results in every run. The unique ability to capture MRM and enhanced product ion confirmation scans in one injection, without the need for long and inefficient chromatography, enables reliable screening for more compounds in each analysis, without compromising data quality.  This all leads to better throughput, without investing more time and resources.